outcome
Leon and Ashley escape because they remove the parasites from their bodies and destroy Saddler's operation, but Ada's stolen sample makes the ending a rescue completed inside a larger bioweapon economy.
Resident Evil 4
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Every ending, what changes it and what it means.
Leon and Ashley escape, but the resolution matters because they defeat the mechanism of control rather than simply its visible leader.
What it means
The ending completes the central question of Resident Evil 4: Leon rescues the president's daughter by surviving a cult that turns infection into control.
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Where this comes from
Every sentence above is built from facts confirmed by at least two independent sources. Sources used: Capcom, IGN.